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Ovarian enzyme activities in women with polycystic ovary syndrome.

Magoffin DA

Department of Obstetrics and Gynecology, Cedars-Sinai Burns and Allen Research Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA. magoffin@cshs.org

Studies using primary ovarian tissue and cultured human theca and granulosa cells have shown that steroidogenic enzyme activities are up-regulated in theca cells in polycystic ovary syndrome (PCOS). Although granulosa cells in arrested follicles in PCOS fail to express significant amounts of aromatase, there is an overexpression of 5alpha-reductase activity and premature expression of cholesterol side-chain cleavage cytochrome P450.

Published 26 June 2006 in Fertil Steril, 86: S9-S11.
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