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A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome.

Wang Y, Wu X, Cao Y, Yi L, Chen J

Human Genetic Identification Laboratory, Medical School of Nanjing University, Nanjing, China.

A (tttta)n microsatellite polymorphism in the promoter of CYP11a gene was investigated in 201 Chinese Han women with polycystic ovary syndrome (PCOS) and 147 control women. The 6/6 genotype was defined with significant difference of CYP11a polymorphism between women with PCOS and control women, and associated with greater BMI in PCOS patients, suggesting a certain role of the six-repeat allele variant in the pathogenesis of Chinese women with PCOS.

Published 4 July 2006 in Fertil Steril, 86(1): 223-6.
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