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Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome.

Evans WS, Taylor AE, Boyd DG, Johnson ML, Matt DW, Jimenez Y, Nestler JE

Department of Medicine, National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville, 22908, USA. wse2p@virginia.edu

OBJECTIVE: To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS). DESIGN: Prospective study in normal and PCOS women. SETTING: General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Massachusetts General Hospital. PATIENT(S): Six normal women and five women with PCOS. INTERVENTION(S): Administration of diazoxide to lower circulating insulin concentrations. MAIN OUTCOME MEASURE(S): Characteristics of LH secretion as appraised by multiparameter deconvolution and estimation of approximate entropy. RESULT(S): Short-term administration of diazoxide had no effect on the secretion of LH in women with PCOS. CONCLUSION(S): Hyperinsulinemia resulting from insulin resistance in women with PCOS may not have a direct effect on gonadotropin secretion.

Published 6 July 2007 in Fertil Steril, 88(1): 118-24.
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